Ace the Certified Nephrology Nurse 2025 Exam – Dive into Dialysis Mastery!

Nicotine is recognized for its ability to decrease the effectiveness of heparin due to its influence on platelet reactivity and potentially altering the coagulation cascade. Nicotine can lead to an increase in platelet aggregation and activation, which counteracts heparin's anticoagulant properties. Heparin works by enhancing the inhibitory effects of antithrombin on thrombin and factor Xa, and any substance that promotes platelet activity may diminish heparin's intended action of preventing clot formation.

In contrast, dopamine primarily acts as a vasopressor and does not have a direct impact on heparin's anticoagulant effects. Quinine, while having some anticoagulant properties, primarily relates to its effect on the heart and muscle cramps rather than having a significant interaction with heparin. Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), provides pain relief and reduces inflammation, but it does not notably alter the effectiveness of heparin. The unique aspect of nicotine's pharmacological action makes it the most relevant choice concerning heparin's efficacy.