Ace the Certified Nephrology Nurse 2025 Exam – Dive into Dialysis Mastery!

Question: 1 / 400

Which of the following medications may decrease the effectiveness of heparin?

Aspirin

Dextran

Nicotine

Nicotine is known to potentially decrease the effectiveness of heparin by promoting platelet activation and aggregation, which can counteract heparin's anticoagulant effects. While heparin is primarily used to prevent or treat blood clots, nicotine may induce a pro-coagulant state, leading to a reduced response to heparin therapy. This relationship is particularly important in patients who smoke or use nicotine products, as their circulatory system may experience altered functionality.

Other medications listed, like aspirin and ibuprofen, are primarily NSAIDs that affect platelet function and may have anticoagulant properties, but they generally do not significantly decrease heparin's effectiveness. Dextran may augment the effects of heparin by providing additional anticoagulation properties. Understanding the pharmacodynamic interactions is crucial for managing patients on heparin therapy effectively and ensuring optimal treatment outcomes.

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Ibuprofen

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