Ace the Certified Nephrology Nurse 2026 Exam – Dive into Dialysis Mastery!

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What is a significant characteristic of calcineurin inhibitors?

They promote T-cell activation

They inhibit T-cell activation

Calcineurin inhibitors are crucial in the management of organ transplant patients and certain autoimmune conditions due to their mechanism of action. They specifically inhibit T-cell activation by blocking the activity of calcineurin, a protein phosphatase that is essential for the activation of T-cells. This inhibition results in the suppression of interleukin-2 (IL-2) production, a vital growth factor for T-cells, thereby leading to reduced immune response. This characteristic is significant as it helps prevent transplant rejection and diminishes the immune response in autoimmune diseases.

While other features associated with calcineurin inhibitors include potential increases in blood pressure and effects on kidney function, these are secondary to their primary action of T-cell inhibition. Understanding this principal characteristic is essential for the application of these drugs in clinical practice and highlights their role as immunosuppressants.

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They increase blood pressure

They decrease kidney function

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